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Metformin HCl is a white to off-white crystalline compound with a molecular formula of C4H11N5HCl and a molecular weight of 16563. It is a lipophilic molecule that possesses highly favourable pharmacokinetic and pharmacodynamic properties.
Metformin HCl is freely soluble in water and is practically insoluble in acetone ether and chloroform.
Ormeloxifene hydrochloride side effects. Ormeloxifene has a few side effects that include Delayed menses Nausea Vomiting Headache Weight gain. Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person.
What are the side effects of Ormeloxifene. Nausea headache rise in blood pressure weight gain and delayed or prolonged menstrual period. What are the other precautions for Ormeloxifene.
Ormeloxifene and Other Contraindications. Polycystic ovarian disease cervical hyperplasia recent history of jaundice or hepatic impairment severe allergic states TB renal impairment. Ormeloxifene acts on oestrogen receptors.
It has a weak estrogenic and potent antiestrogenic actions. It is expected to exert a contraceptive effect and normalise the bleeding from uterine cavity by regularising the expression of oestrogen receptors on. Side effects whereas GnRh analogue are much costly and also associated with increase occurrence of vasomotor symptoms and osteoporosis.
Progesterone is the most commonly. Side effects of Sevista Nausea headache rise in blood pressure weight gain and delayed or prolonged menstrual period. Dosage When it is to be taken Indications.
Ormeloxifene hydrochloride indicated for emergency contraceptive and dysfunction al uterine bleeding making fast dissolving tablet i s most opt for these indications. Though ormeloxifene can be used as a contraceptive agent but it is also used in this conditions due to its antiestrogenic action. If you are married and planning for baby then you should avoid it.
Otherwise you can take it as prescribed by your doctor. Regarding its side effects irregular period is most important. You should wait for it.
The study validates the use of ormeloxifene drug for its easy administration with minimal risk and side effects. The results suggested that there is a significant increase in Hb level P 00001 and decrease in ET P 00001 as because ormeloxifene has anti-proliferative effect on endometrium which causes endometrial atrophy leading to decrease in menstrual blood loss. Page 5 of 8 Boiling Point10858oC 760 mm Hg for 2022 HCl in water 83 C 760 mm Hg for 31 HCl in water 505oC for 37 HCl in water Melting Point.
-6225oC -80F 2069 HCl in water -462oC 3124 HCl in water -254oC 3917 HCl in water Critical Temperature. Not available Specific Gravity. 11- 119 Water 1 110 20 and 22 HCl solutions 112 24 HCl.
Ormeloxifene has many advantages as a contraceptive drug including 1 this is a once a week oral pill 30 mg dose weekly 2 it has long serum half-life 3 it has very few to no side effects since it does not affect ovulation or the levels of female hormone and 4 it provides an opportunity for effective and efficient reversal of fertility upon discontinuation of the drug. ORMELOXIFENE Has an excellent safety profilevery well tolerated practically without any undesirable side effects Easy to administer- practically without any undesirable side effects Two 60mg tablets twice a week for examplS d Wd d f 12le Sunday Wednesday for 12 weeks followed by one tablet of 60mg twice a week for another 12 weeks. The safety profile of Ormeloxifene is excellent with very few side effects like nausea headache and weight gain delayed or prolonged menstrual period.
Main side-effect is ovarian enlargement and delay in menstruation causing confusion and tension. With Ormeloxifene for 48 h the cell viability of Hela cells was significantly decreased 10 and 20 μM. P.
Effects of Ormeloxifene on cell-cycle phase distribution of HeLa cells. Cells were incubated with 0 10. Common side effects include hot flashes leg cramps swelling and joint pain.
Severe side effects may include blood clots and stroke. Use during pregnancy may harm the baby. The medication may worsen menstrual symptoms.
Ormeloxifene is a member of type-1 class of non-steroidal SERMs in clinical use which possesses desirable bone-protective and lipid lowing activities of estrogen and reported to prevent advanced breast cancer in both women and men without side effects associated with conventional HRTERT. The precise mechanism by which ormeloxifene. Side Effects Dizziness Headache Somnolence Tremor Blurred vision Tinnitus Sinus congestion Nausea Diarrhea Abdominal pain Dry mouth Fatigue Insomnia Hypertension.
Ormeloxifene ORM is a drug widely used for the treatment of breast cancer. It is a lipophilic molecule that possesses highly favourable pharmacokinetic and pharmacodynamic properties. The anti-cancer activity of ORM can be improved by developing a formulation that offers targeted delivery.
This can be achieved by encapsulation using. Metformin HCl is a white to off-white crystalline compound with a molecular formula of C4H11N5HCl and a molecular weight of 16563. Metformin HCl is freely soluble in water and is practically insoluble in acetone ether and chloroform.
The pKa of metformin is 124. The pH of a 1 aqueous solution of metformin hydrochloride is 668.